[Simnibs-discuss] using simNIBS in brain injury populations

Axel Thielscher axelt at drcmr.dk
Tue Mar 29 15:02:54 CEST 2022

Dear Athena,

this is a good question which is not easy to answer. I would assume that 
the conductivity changes in gray and white matter correlate roughly with 
the diffusion changes seen in DTI. So a first step could be to simply 
quantify the diffusion changes compared to healthy subjects to get an 
initial impression on whether adjustments of the conductivity values 
might be needed.

You can map the results back to subject-specific nifti or to MNI (using 
eg. the options menu in the GUI) to read out voxel-specfic values.

Best regards,


On 3/23/2022 7:51 AM, Athena Stein wrote:
> Hi,
> I was wondering how accurate simNIBS is when used in a brain with 
> injury (especially diffuse axonal injury, gliosis etc.). e.g. is 
> simNIBS able to do any kind of voxel-wise analysis which might capture 
> these diffuse injuries?
> I am hoping to use simNIBS to look into reverse calculation of tDCS 
> needed in an attempt to standardise current dose at the cortex.
> Thank you for all of your work – I am a big simNIBS fan!
> Thanks
> Athena
> *Athena Stein*
> *FHEA MPH BBiomedSc*
> PhD Candidate
> Casual Academic
> UQ Child Health Research Centre
> Acquired Brain Injury in Children research program (ABiC)
> Centre for Children’s Health Research
> Level 6, 62 Graham St
> South Brisbane Qld 4101 Australia
> *T* +61 7 3069 7555
> *E*a.stein at uq.edu.au 
> <mailto:a.stein at uq.edu.au>*W*child-health-research.centre.uq.edu.au 
> <https://child-health-research.centre.uq.edu.au/>
> CRICOS 00025B
> _______________________________________________
> Simnibs-discuss mailing list
> Simnibs-discuss at drcmr.dk
> https://mailman.drcmr.dk/mailman/listinfo/simnibs-discuss

Dr. Axel Thielscher
Professor of Neurophysics and Neuroimaging
Danish Research Center for Magnetic Resonance
Copenhagen University Hospital Hvidovre
DK-2650 Hvidovre, Denmark
Department of Health Technology
Technical University of Denmark
DK-2800 Kgs. Lyngby
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