[Simnibs-discuss] differences and solutions for stroke brain - CHARM - HEADRECO

Oula oulap at drcmr.dk
Tue Aug 9 10:23:12 CEST 2022

Hi Witold,

CHARM was tested only on healthy appearing subjects without large 
pathologies. I think the problem here is that as the subject brain 
anatomy differs from the anatomical atlas substantially, the algorithm 
starts modeling CSF as WM. This can be solved by tweaking the parameters 
of CHARM, but in order to do that I would need a few examples of the 
scans you're using if possible.


On 8/6/22 10:43, w.tomasz at sensusmed.pl wrote:
> Hi everyone,
> I wanted to ask how the conduction issue will be resolved in people 
> after strokes and brain injuries.(optimization multifocal of tDCS/tACS 
> stimulation)
> In headreco, the lesions were filled with cerebrospinal fluid, in 
> CHARM it is a clump of mainly white matter and gray sections. As we 
> know, quite a big difference.
> On the same source file, we have big differences, Headreco is much 
> better at dealing with dilated cerebral ventricles etc. CHARM fills 
> them with gray matter, in addition, the boundaries of gray matter and 
> white matter are very divergent over the entire surface.
> Such problems will not arise in other models in healthy people, made 
> with the same sequences on the same MR as in a stroke survivor.
> Pictures in the attachment.
> I will appreciate your help and suggestions.
> Best,
> -- 
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> Simnibs-discuss at drcmr.dk
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