[Simnibs-discuss] Adding tumour tissue to mesh

Axel Thielscher axelt at drcmr.dk
Wed Dec 22 16:04:11 CET 2021


sorry for following up on these topics rather late. Regarding Alzheimer 
or MCI, I don't think that specific adjustments are needed for the 
electric field calculations. The structural differences (atrophy) will 
be reflected in the segmentation results when generating headmodels from 
MR data of these patients, and thus be taken into account during the 
e-field simulations. Obviously, e-field simulations do not provide 
information about disease-related physiological changes that might alter 
the response to brain stimulation, for which other information is 
required in addition.

Regarding the addition of tumor tissues, the short answer is that 
SimNIBS is not good in dealing with this so far, but will get much 
better next year.

Best regards,


On 9/20/2021 9:18 AM, Utkarsh Pancholi wrote:
> Hi,
> Indeed a great question from Stephen. I would also like to ask a 
> similar question. Is there any way to include pathological 
> abnormalities like in Alzheimer's disease and MCI (Loss of Neural 
> tissue mass)?  How we can relate the generated E-field for validation 
> and their effects on physiological/ neuronal/ functional changes 
> within the target area.
> -----------------------------------------------------------------------------------------------------
> On Mon, Sep 20, 2021 at 12:34 PM Stephen Hogg <SHogg at emvision.com.au> 
> wrote:
>     Hi,
>     Thanks for making SimNIBS, it's a great program. I was wondering
>     if I could ask a few questions about including pathologies in the
>     outputs. Specifically, I have a region of the brain that I want to
>     overwrite with a tissue type not produced by SimNIBS itself (e.g.
>     tumour tissue). In order to include the tumour tissue in the
>     meshes, do I need to add an extra .nii file in the mask_prep
>     directory after updating the existing masks? If so, are there any
>     considerations I should be aware of? How is the new tissue type
>     incorporated in mesh generation? Hope this isn't a bother, would
>     greatly appreciate any light you could shed on this.
>     Regards,
>     Stephen
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Dr. Axel Thielscher
Professor of Neurophysics and Neuroimaging
Danish Research Center for Magnetic Resonance
Copenhagen University Hospital Hvidovre
DK-2650 Hvidovre, Denmark
Department of Health Technology
Technical University of Denmark
DK-2800 Kgs. Lyngby
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