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<p>Hi,</p>
<p>sorry for following up on these topics rather late. Regarding
Alzheimer or MCI, I don't think that specific adjustments are
needed for the electric field calculations. The structural
differences (atrophy) will be reflected in the segmentation
results when generating headmodels from MR data of these patients,
and thus be taken into account during the e-field simulations.
Obviously, e-field simulations do not provide information about
disease-related physiological changes that might alter the
response to brain stimulation, for which other information is
required in addition.<br>
</p>
<p>Regarding the addition of tumor tissues, the short answer is that
SimNIBS is not good in dealing with this so far, but will get much
better next year.<br>
</p>
<p>Best regards,</p>
<p>Axel</p>
<p><br>
</p>
<div class="moz-cite-prefix">On 9/20/2021 9:18 AM, Utkarsh Pancholi
wrote:<br>
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<blockquote type="cite"
cite="mid:CAFvJZmj-Kgh73O05oOA4f-12BnPBjSDOygcNbcnvmMPqDA24yg@mail.gmail.com">
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<div dir="ltr">Hi,
<div><br>
</div>
<div>Indeed a great question from Stephen. I would also like to
ask a similar question. Is there any way to include
pathological abnormalities like in Alzheimer's disease and MCI
(Loss of Neural tissue mass)? How we can relate the generated
E-field for validation and their effects on physiological/
neuronal/ functional changes within the target area. <br
clear="all">
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<div><span style="color:rgb(56,118,29)"><font
size="2">-----------------------------------------------------------------------------------------------------<br>
UTKARSH V. PANCHOLI<br>
</font></span></div>
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<div class="gmail_quote">
<div dir="ltr" class="gmail_attr">On Mon, Sep 20, 2021 at 12:34
PM Stephen Hogg <<a href="mailto:SHogg@emvision.com.au"
moz-do-not-send="true" class="moz-txt-link-freetext">SHogg@emvision.com.au</a>>
wrote:<br>
</div>
<blockquote class="gmail_quote" style="margin:0px 0px 0px
0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
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<div
style="font-family:Calibri,Arial,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0);background-color:rgb(255,255,255)">Hi,</div>
<div
style="font-family:Calibri,Arial,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0);background-color:rgb(255,255,255)"><br>
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<div
style="font-family:Calibri,Arial,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0);background-color:rgb(255,255,255)">Thanks
for making SimNIBS, it's a great program. I was wondering
if I could ask a few questions about including pathologies
in the outputs. Specifically, I have a region of the brain
that I want to overwrite with a tissue type not produced
by SimNIBS itself (e.g. tumour tissue). In order to
include the tumour tissue in the meshes, do I need to add
an extra .nii file in the mask_prep directory after
updating the existing masks? If so, are there any
considerations I should be aware of? How is the new tissue
type incorporated in mesh generation? Hope this isn't a
bother, would greatly appreciate any light you could shed
on this.</div>
<div
style="font-family:Calibri,Arial,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0);background-color:rgb(255,255,255)"><br>
</div>
<div
style="font-family:Calibri,Arial,Helvetica,sans-serif;font-size:12pt;color:rgb(0,0,0);background-color:rgb(255,255,255)">Regards,<br>
Stephen</div>
</div>
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<pre class="moz-signature" cols="72">--
Dr. Axel Thielscher
Professor of Neurophysics and Neuroimaging
Danish Research Center for Magnetic Resonance
Copenhagen University Hospital Hvidovre
DK-2650 Hvidovre, Denmark
<a class="moz-txt-link-abbreviated" href="http://www.drcmr.dk">www.drcmr.dk</a>
&
Department of Health Technology
Technical University of Denmark
DK-2800 Kgs. Lyngby
<a class="moz-txt-link-freetext" href="http://www.healthtech.dtu.dk/">http://www.healthtech.dtu.dk/</a></pre>
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