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<p>Hi Martin,</p>
<p><br>
</p>
<p>in general terms, the tdcs optimization tries to focus the
currents on the target region(s) while avoiding all the rest (the
"rest" is determined as all surfaces except the target regions).
By including CSF and skull into the leadfield, you basically ask
the optimization to avoid those surfaces as well, and this then
will cause changes in your optimization results.<br>
</p>
<p><br>
</p>
<p>Best regards,</p>
<p>Axel</p>
<p><br>
</p>
<div class="moz-cite-prefix">On 18-05-2022 19:51, Martin Bardhi
wrote:<br>
</div>
<blockquote type="cite"
cite="mid:QB1PR01MB27716E052F1E1D1F814DA025F7D19@QB1PR01MB2771.CANPRD01.PROD.OUTLOOK.COM">
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<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Hello, <br>
My name is Martin B and I am a university student researched
using simNibs tDCS optimization feature for my project. When
testing some of the functionality of the optimization scripts I
found that if I include different tissues in the leadfield (CSF
and skull surfaces for example (1003,1004) ) the resulting
optimization will have different electrode placements (even when
I then exclude these tissues from target.tissues(). <br>
I am a little confused as to what including these tissues in the
leadfield does, as I initially thought it just meant that
electric field would be recorded there but I have now found that
it changes the optimization in some way. So, my question is:
what does including different tissues in the leadfield do. And
if I wanted to obtain an optimization that would be best
reflective of real-world results, what tissues should I include
(if any)?<br>
<br>
Thanks,<br>
<br>
Martin</div>
<div style="font-family: Calibri, Arial, Helvetica, sans-serif;
font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
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<br>
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<pre class="moz-quote-pre" wrap="">_______________________________________________
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</pre>
</blockquote>
<pre class="moz-signature" cols="72">--
Dr. Axel Thielscher
Professor of Neurophysics and Neuroimaging
Danish Research Center for Magnetic Resonance
Copenhagen University Hospital Hvidovre
DK-2650 Hvidovre, Denmark
<a class="moz-txt-link-abbreviated" href="http://www.drcmr.dk">www.drcmr.dk</a>
&
Department of Health Technology
Technical University of Denmark
DK-2800 Kgs. Lyngby
<a class="moz-txt-link-freetext" href="http://www.healthtech.dtu.dk/">http://www.healthtech.dtu.dk/</a></pre>
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