<div dir="ltr">Hi Matthias, thank you for your interest in simNIBS and sorry about the late reply.<div>Due to the physical constraints optimization of single points will actually affect a quite large area, typically there is a tradeoff between focality and maximum achieved field strength, which will already be embodied in the optimization. We would generally suggest splitting the optimization into individual points (only really relevant if the region is quite large) rather than using network optimization feature as it  the network optimization feature (<a href="https://simnibs.github.io/simnibs/build/html/tutorial/advanced/tdcs_distributed_opt.html">https://simnibs.github.io/simnibs/build/html/tutorial/advanced/tdcs_distributed_opt.html</a>) as that can be somewhat counterintuitive and difficult to control - and also enforces positive negative fields rather than the norm.</div><div>Best,</div><div>Kristoffer</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Mon, 11 Oct 2021 at 18:47, Matthias Mittner <<a href="mailto:matthias.mittner@uit.no">matthias.mittner@uit.no</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">





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<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt">Hi,<u></u><u></u></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt"><u></u> <u></u></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt">Is it possible to optimize the overlap of the Enorm with a ROI instead of a single target coordinate? The tutorial at
<a href="https://simnibs.github.io/simnibs/build/html/tutorial/tms_optimization.html" target="_blank">
https://simnibs.github.io/simnibs/build/html/tutorial/tms_optimization.html</a> only seems to mention individual target coordinates.<u></u><u></u></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt">I am thinking about a TMS protocol but tDCS would also be interesting.<u></u><u></u></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt"><u></u> <u></u></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt">Best,<u></u><u></u></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt"><u></u> <u></u></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt">Matthias<u></u><u></u></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:11pt"><u></u> <u></u></span></p>
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